Homma S., Hirose N., Ishida H., Ishii T., Araki G. "Carotid intima-media thickness as a biomarker of subclinical atherosclerosis". Bauer M., Caviezel S., Teynor A., Erbel R., Mahabadi A.A., Schmidt-Trucksäss A. "Measurement of arterial wall thickness as a surrogate marker for atherosclerosis". de Groot E., Hovingh G.K., Wiegman A., et al.
"Age and gender differences of endothelial function in 4739 healthy adults: the HUNT3 Fitness Study". Skaug E.A., Aspenes S.T., Oldervoll L., et al. "Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans". Thijssen D.H.J., Bruno R.M., van Mil A.C.C.M., et al. Poulter N.R., Prabhakaran D., Caulfield M. "Central artery stiffness in hypertension and aging: a problem with cause and consequence". Humphrey J.D., Harrison D.G., Figueroa C.A., Lacolley P., Laurent S. "Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients". Laurent S., Boutouyrie P., Asmar R., et al. "Arterial stiffness and cardiovascular events: the Framingham Heart Study". Mitchell G.F., Hwang S.J., Vasan R.S., et al. "Recommendations for improving and standardizing vascular research on arterial stiffness: a scientific statement from the American Heart Association". Townsend R.R., Wilkinson I.B., Schiffrin E.L., et al. "Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity". Van Bortel L.M., Laurent S., Boutouyrie P., et al. "Vascular compliance as a measure of biological age". "Long-term association of low-density lipoprotein cholesterol with cardiovascular mortality in individuals at low 10-year risk of atherosclerotic cardiovascular disease". Abdullah S.M., Defina L.F., Leonard D., et al.
Chronological age versus biological age free#
"Growth hormone, insulin-like growth factor-1, insulin resistance, and leukocyte telomere length as determinants of arterial aging in subjects free of cardiovascular diseases". Strazhesko I.D., Tkacheva O.N., Akasheva D.U., et al. "Gut microbiota: a player in aging and a target for anti-aging intervention". "Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty".
Chronological age versus biological age drivers#
"Somatic mutations and clonal hematopoiesis: unexpected potential new drivers of age-related cardiovascular disease". "The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis". Fransquet P.D., Wrigglesworth J., Woods R.L., Ernst M.E., Ryan J. "DNA methylation age of blood predicts all-cause mortality in later life". Marioni R.E., Shah S., McRae A.F., et al. "DNA methylation age of human tissues and cell types". "Genome-wide methylation profiles reveal quantitative views of human aging rates". "Distinct DNA methylomes of newborns and centenarians". "Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population". "Telomere length as cardiovascular aging biomarker: JACC review topic of the week". De Meyer T., Nawrot T., Bekaert S., De Buyzere M.L., Rietzschel E.R., Andrés V. "Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection". López-Otín C., Blasco M.A., Partridge L., Serrano M., Kroemer G. Laurent S., Boutouyrie P., Cunha P.G., Lacolley P., Nilsson P.M. "Association between advanced age and vascular disease in different arterial territories: a population database of over 3.6 million subjects". Savji N., Rockman C.B., Skolnick A.H., et al. "Aging in the cardiovascular system: lessons from Hutchinson-Gilford progeria syndrome". This review summarizes the current knowledge on biological age biomarkers, factors influencing biological aging, and antiaging interventions, with a focus on vascular aspects of the aging process and its cardiovascular disease related manifestations.ġ. However, strategies to extend health span and life span require understanding of interindividual differences in age-dependent functional decline, known as biological aging. Studies in experimental models and humans have identified 9 highly interconnected hallmark processes driving mammalian aging. In a progressively aging population, it is essential to develop early-life biomarkers that efficiently identify individuals who are at high risk of developing accelerated vascular damage, with the ultimate goal of improving primary prevention and reducing the health care and socioeconomic impact of age-related cardiovascular disease. Aging is the main risk factor for vascular disease and ensuing cardiovascular and cerebrovascular events, the leading causes of death worldwide.
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