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B Cells and Autoimmunity 139 STUART TANGYE AND FABIENNE MACKAYĤ. General Features of Autoimmune Diseases 25ġ1. Peptide-Based Instruction of Suppressor Commitment in Naïve T Cells 133 IRINA APOSTOLOU, KARSTEN KRETSCHMER, AND HARALD VON BOEHMERģ. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity 11ġ0. Regulatory T Cells 119 SIMON READ, KEVIN J.

Autoimmunity: A History of the Early Struggle for Recognition 3ĩ. Tolerance and Autoimmunity: T Cells 103 MATTHEW A. Section I Immunologic Basis of AutoimmunityĨ. Prospectus: The Road to Autoimmune Disease xix Color Plate between pages Role of Th1 and Th2 Cells in Autoimmunity 83 Working together to grow libraries in developing countriesħ. Steinmann Marketing Manager: Katherine Clevengerįor all information on all Elsevier Academic Press Publications visit our Web site at | | Printed in the United States of America. To the fullest extent of the law, neither the Publisher nor the Editors assume any liability for any injury and/or damage to persons or property arising out or related to any use of the material contained in this book.Īcquisitions Editor: Margaret MacDonald Developmental Editor: Victoria Lebedeva Publishing Services Manager: Melissa Lastarria Project Manager: Kelly E.M. It is the responsibility of the practitioner, relying on their own experience and knowledge of the patient, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. Readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. As new research and experience broaden our knowledge, changes in practice, treatment, and drug therapy may become necessary or appropriate. Notice Knowledge and best practice in this field are constantly changing. e-mail: You may also complete your request on-line via the Elsevier homepage (), by selecting “Customer Support” and then “Obtaining Permissions.” Permissions may be sought directly from Elsevier’s Science and Technology Rights Department in Oxford, U.K.: telephone: (+44) 1865 843830, fax: (+44) 1865 853333. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Except Chapter 23, which is in the public domain. THE AUTOIMMUNE DISEASES, FOURTH EDITION Copyright © 2006, Elsevier Inc. Mackay Department of Biochemistry and Molecular Biology Monash University Clayton, Victoria Australiaġ1830 Westline Industrial Drive, St. Rose Departments of Pathology and of Molecular Microbiology and Immunology The Johns Hopkins University Baltimore, Maryland